Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy
نویسندگان
چکیده
منابع مشابه
Inhibition of Midkine Augments Osteoporotic Fracture Healing
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton. As Mdk-deficient mice were protected from ovariectomy (OVX)-induced bone loss, this factor may also play a role in the pathogenesis of postmenopausal osteoporosis. We have previously demonstrated that Mdk negatively influences bone ...
متن کاملlocal erythropoietin injection in tibiofibular fracture healing
conclusions epo injection into the site of tibiofibular fractures may possibly accelerate healing. background erythropoietin (epo), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. animal studies have suggested a role for erythropoietin in bone healing. objectives the present study aimed to evaluate the effects of local epo...
متن کاملLocal Erythropoietin Injection in Tibiofibular Fracture Healing
BACKGROUND Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing. OBJECTIVES The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures. MATERIALS AND METHODS In a prospective double ...
متن کاملThe temporal and spatial development of vascularity in a healing displaced fracture.
Underlying vascular disease is an important pathophysiologic factor shared among many co-morbid conditions associated with poor fracture healing, such as diabetes, obesity, and age. Determining the temporal and spatial patterns of revascularization following a fracture is essential for devising therapeutic strategies to augment this critical reparative process. Seminal studies conducted in the ...
متن کاملQueries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing
We would like to congratulate Dr. Bakhshi and colleagues for being the first group to publish scientific evidence regarding the osteogenic effect of erythropoietin (EPO) in a clinical trial (1). As you correctly report, several preclinical studies have shown the efficacy of Erythropoietin to increase bone healing at early time points (2-4).In agreement with your approach, we strongly believe th...
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ژورنال
عنوان ژورنال: Bone
سال: 2013
ISSN: 8756-3282
DOI: 10.1016/j.bone.2012.10.014